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KMID : 0606920060140040235
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Biomolecules & Therapeutics
2006 Volume.14 No. 4 p.235 ~ p.239
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Effect of Imperatorin on Adenosine Triphosphate-stimulated Mucin Secretion from Airway Epithelial Cells
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Heo Ho-Jin
Kim Cheol-su
Lee Hyun-Jae
Shin Seung-won
Kim Yeong-Shik
Kang Sam-Sik
Park Yang-Chun
Kim Yun-Hee
Seo Un-Kyo
Seok Jeong-Ho
Lee Choong-Jae
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Abstract
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Angelicae Koreanae Radix has been used for controlling inflammatory respiratory diseases in folk medicine and their components, imperatorin. marmesinin and oxypeucedanin were reported to have diverse bio- logical effects. In this study, we investigated whether imperatorin, marmesinin and oxypeucedanin affect ade- nosine triphosphate (ATP)-induced mucin secretion from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using 3H-glucosamine for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on 3H-mucin secretion. The results were as follows ; 1) imperatorin significantly inhibited ATP-induced mucin secretion ; 2) However, marmesinin and oxypeucedanin did not affect ATP-induced mucin secretion, significantly. We con- clude that imperatorin might inhibit ATP-induced mucin secretion by directly acting on airway mucin-secreting cells. Therefore, imperatorin should further be investigated for the possible use as mucoregulators in the treatment of inflammatory airway diseases.
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KEYWORD
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Airway, Mucin, Imperatorin, Marmesinin, Oxypeucedanin
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